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Zulekha Nishad, based in India, is a skilled content specialist, copy editor, and creative content writer with a Master's degree in English Language and Literature. Read more
Last Updated August 21, 2025
Blood on a mattress is one of those things you never really plan for, but it happens. Maybe you woke up with a nosebleed, or your period caught you off guard in the middle of the night. Whatever the reason, you’re left with a dark, obvious stain that feels almost impossible to deal with. The good news is that you don’t need expensive cleaning sprays or complicated hacks to fix it. With some household basics and a little patience, you can usually get your mattress looking clean again.
Key Takeaways:
Fresh blood stains are always easier to deal with than dried ones. When the blood is still wet, the proteins haven’t had time to sink in and set. Sometimes, cold water alone is enough to make a fresh stain disappear.
Once the blood dries, the story changes. You can still remove it, but it takes more time, more effort, and sometimes a couple of different methods.
The #1 Rule: Never use hot water. Heat “cooks” the proteins in the blood, locking them into the fabric permanently. That means no hot water, no warm cycles in the washing machine for bedding, and no hot-air drying until the stain is gone.
A little prep can make the actual cleaning a lot easier.
Fresh blood is your easiest scenario. As we said in the beginning, if you act quickly, you can usually remove it completely with minimal effort.
You’ll need:
Detailed Steps:
A set blood stain is harder to clean because the proteins have already bonded deep into the mattress fibers.
You’ll need:
Detailed Steps:
Enzyme-based cleaners work by breaking down the proteins in blood, which makes them a great choice for stubborn or large stains.
You’ll need:
Steps:
Mattress stains are a pain, but bedding is much simpler to clean.
Fresh stains:
Dried stains:
If the stain is large and really set in, or you’re nervous about damaging your mattress, professional mattress cleaners have the tools to handle it safely.
Blood stains on a mattress might look intimidating, but they don’t have to be permanent. If you act quickly, use cold water, and are patient with the process, you can usually erase them completely. And if the stain is stubborn, you have enzyme cleaners and professional help as backup. With the right approach, no one will ever know the stain was there.
Hot water is never your best friend when it comes to bloodstain removal. Heat locks proteins into the affected area at a molecular level, turning a fresh spot into a set stain.
The best bet is to act fast with cold water and a clean white towel. This keeps the stained part from spreading and gives you a much better chance of saving your mattress or white sheets.
Hydrogen peroxide can be effective for stain removal, but it may lighten delicate fabrics or leave marks on sheets.
Always test one tablespoon on a hidden part of the mattress before using it on the affected area.
Using chlorine bleach on a mattress is not a good idea. While bleach may work for other stains like mildew or ink, it can damage fabrics, leave strong odors, and be harmful if not rinsed completely.
In a laundry room, bleach may work for white cotton bed sheets, but for mattresses, it’s safer to use white vinegar, lemon juice, or natural enzymes instead. These options protect your mattress while still lifting stains.
When you’re dealing with older stains, it takes more effort since the blood has already bonded at a molecular level. Don’t panic, because accidents happen. Start with gentle blotting, then try an enzyme cleaner, the cornstarch method (make a paste by mixing cornstarch with a little cold water, spread it over the stain, let it dry in the sun, and then brush or vacuum it off), or even white vinegar. If the stain persists, repeat the process on the affected area until you see progress.
After working on bloodstain removal, your mattress needs plenty of time to air dry. Depending on how much water or solution was used, it can take anywhere from 8 to 24 hours.
To speed things up, place the mattress near a window for airflow or set up fans in your laundry room. Always be sure it’s completely dry before remaking the bed to keep your mattress clean and odor-free.
Yes, a mattress protector makes a big difference in keeping your mattress clean. A waterproof protector creates a barrier that prevents liquids from soaking in, which means you won’t have to struggle to get blood stains or other spills out later. Even if bloodstain removal becomes necessary on your bed sheets, your mattress itself will stay safe.
Period stains are common and can be cleaned effectively if treated quickly. Always start with cold water and gently dab the area to lift as much of it out as possible. If the stain lingers, you can try sprinkling salt or using the meat tenderizer method. To do this, mix a small amount of unseasoned meat tenderizer with cold water to create a paste, then gently rub it onto the stained spot. Let it sit for about 15-30 minutes before rinsing with cold water. The enzymes in the tenderizer help break down the proteins in blood, making the stain easier to wash away.
If you don’t let the mattress dry completely after cleaning, a damp or musty smell can develop. To prevent this, air dry thoroughly and sprinkle baking soda to neutralize odors. Using white vinegar during bloodstain removal also helps freshen the surface.
Tough stains take more effort and a bit of patience to handle. Start by vacuuming the area to remove any loose debris and surface dirt. Next, dab gently with cold water as this helps loosen the fibers and prevent the stain from setting in further.
Enzyme-based cleaners or natural enzymes can be very effective at breaking down the proteins in dried blood. Apply the cleaner, let it sit for 15-20 minutes, and then blot with a clean cloth. If the stain is still visible, try alternating between white vinegar and baking soda. The fizzing action helps lift particles from deep within the fabric.
For particularly stubborn or very old stains, hydrogen peroxide (3% solution) can be used, but always spot test on a hidden area of the mattress first to make sure it doesn’t cause discoloration. Apply a small amount, let it bubble for a few minutes, then blot away with a damp cloth.
If the stain has been there for a long time and nothing seems to work, professional cleaning may be the most reliable way to restore your mattress to a fresh and hygienic state.
Related blog posts:
1. How to Clean a Mattress the Right Way?
2. How to Get Pee Out of a Mattress
3. How to Get Blood Out of Sheets?
4. How to Clean a Mattress Topper?
Disclaimer: What is said in this article has been referenced from multiple sources and is intended only for educational and informational purposes. Please note that no content in this article is a substitute for professional advice from a qualified doctor or healthcare provider. Always consult an experienced doctor with any concerns you may have regarding a health condition or treatment, and never disregard any medical suggestions or delay in seeking treatment because of something you read here.
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